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KMID : 0359719950130041007
Journal of the Korean Neurological Association
1995 Volume.13 No. 4 p.1007 ~ p.1010
A Case of Diffuse Leukoencephalopathy Caused by 5-Fluorouracil
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Abstract
5-Fluorouracil is one of the most commonly used anticancer drug. We report a case of leukoencephalopathy who had received 5-fluorouracil injection following operation of carcinoid tumor in intestine. The case had dementia, dysarthria and gait
disturbance.
Brain CT showed bilaterally symmetric diffuse low densities in the white matte rof cerebrum and cytologic examination of cerebrospinal fluid was negative for malignancy.
Discontinuation of 5-fluorouracil injection for several days and then improved the clinical symptoms.
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